Ayatollah Ali Khamenei called Israel a pack of “rabid dogs,” in scathing remarks against the Jewish state and its allies this week.

“Zionist officials cannot be called humans, they are like animals, some of them,” said Khamenei. “The Israeli regime is doomed to failure and annihilation.”

“[The] Zionist regime” says things that “only bring humiliation on themselves.” Khamenei added that Israel “emerged through force, and no phenomenon that has emerged through force has continued to exist–and this regime will not continue to exist either.”

He also called any nation that claims Iran is a global threat a “rabid dog of the region, namely the Zionist regime,” according to Iran’s Tasnim News Agency.

The Iranian spiritual leader was referencing current talks between the P5+1 powers and the Islamic republic to come to a deal on Iran’s nuclear program.

Khamenei also took aim at France, one of the P5+1 negotiating powers, for blocking a potential deal last week and assuring Israel Sunday it would remain adverse to an ease on Iranian economic sanctions.

French officials, Khamenei said, were “not only succumbing to the United States, but they are kneeling before the Israeli regime.”

Though the Ayatollah has a long history of vitriol against the Jewish state and the western world, they were words French President Francois Hollande did not take lightly.

“The president said Ali Khamenei’s words on Israel are unacceptable and complicate negotiations,” French government spokeswoman Najat Vallaud-Belkacem said after a cabinet meeting with Hollande.